Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults

作者：Haoneng Tang, Ning Liu, Xiaojing Feng, Yanyi Yang, Yiyuan Fang, Siqi Zhuang, Yufeng Dai, Meilian Liu, Lingli Tang · 发表于：Journal of Translational Medicine · 年份：2021 · DOI：10.1186/s12967-021-02711-x · 被引用次数：38 · 研究领域：IL-33, ST2, and ILC Pathways、Eosinophilic Esophagitis、Inflammasome and immune disorders

BACKGROUND: Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans remains largely unknown. We aimed to address this gap by determining IL-33 serum level and its downstream type 2 inflammatory cytokines interleukin-5 (IL-5) and interleukin-13 (IL-13) in overweight/obese population, and analyzing the specific associations between IL-33 and obesity metabolic phenotypes. METHODS: 217 subjects were enrolled and divided into three groups: healthy control (HC) subjects, metabolically healthy overweight/obese (MHOO) subjects and metabolically unhealthy overweight/obese (MUOO) subjects. Circulating levels of IL-33, IL-5 and IL-13 were measured using ELISA analyses. Multivariate regression analyses were further performed to determine the independent association between IL-33 and obesity metabolic phenotypes. RESULTS: Circulating levels of IL-33 were significantly elevated in subjects of MUOO group compared with HC group and MHOO group, while no significant difference was observed between the latter two groups in IL-33 levels. Consistent with this, serum levels of IL-5/13 were higher in the MUOO group compared with HC and MHOO groups. After adjusted for all confounders, MUOO phenotype was significantly associated with increased IL-33 serum levels (OR = 1.70; 95% CI 1.09-2.64; p = 0.019). With the MHOO group as the reference population,...