The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

作者：Joseph D. Orkin, Michael J. Montague, Daniela Tejada-Martínez, Marc de Manuel, Javier del Campo, Saúl Cheves Hernández, Anthony Di Fiore, Claudia Fontsere, Jason A. Hodgson, Mareike C. Janiak, Lukas F. K. Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H. Perry, Carmen Soto Valverde, Jia Tang, Wesley C. Warren, João Pedro de Magalhães, Shoji Kawamura, Tomàs Marquès‐Bonet, Roman Krawetz, Amanda Melin · 发表于：Proceedings of the National Academy of Sciences · 年份：2021 · DOI：10.1073/pnas.2010632118 · 被引用次数：59 · 研究领域：Primate Behavior and Ecology、Animal Behavior and Reproduction、Bat Biology and Ecology Studies

Through high-depth sequencing of DNA derived from blood, various tissues, and feces via fluorescence-activated cell sorting (fecalFACS) to isolate monkey epithelial cells, we compared genomes of capuchin populations from tropical dry forests and lowland rainforests and identified population divergence in genes involved in water balance, kidney function, and metabolism. Through a comparative genomics approach spanning a wide diversity of mammals, we identified genes under positive selection associated with longevity and brain development. Additionally, we provide a technological advancement in the use of noninvasive genomics for studies of free-ranging mammals. Our intra- and interspecific comparative study of capuchin genomics provides insights into processes underlying local adaptation to diverse and physiologically challenging environments, as well as the molecular basis of brain evolution and longevity.