A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

作者：Sijin Cheng, Ziyi Li, Ranran Gao, Baocai Xing, Yunong Gao, Yu Yang, Shishang Qin, Lei Zhang, Hanqiang Ouyang, Peng Du, Liang Jiang, Bin Zhang, Yue Yang, Xiliang Wang, Xianwen Ren, Jin‐Xin Bei, Xueda Hu, Zhaode Bu, Jiafu Ji, Zemin Zhang · 发表于：Cell · 年份：2021 · DOI：10.1016/j.cell.2021.01.010 · 被引用次数：1670 · 研究领域：Single-cell and spatial transcriptomics、Immune cells in cancer、Chemokine receptors and signaling

cDCs revealed their differences in transcription factors and external stimulus. Additionally, pro-angiogenic tumor-associated macrophages (TAMs) were characterized with diverse markers across different cancer types, and the composition of TIMs appeared to be associated with certain features of somatic mutations and gene expressions. Our results provide a systematic view of the highly heterogeneous TIMs and suggest future avenues for rational, targeted immunotherapies.