A case of lymphomatoid papulosis type E in a young adult: An uncommon entity

作者：Meghana Rajashekara Swamy, Samara Pollock, Lynne J. Goldberg, Lisa Y. Shen · 发表于：Journal of Cutaneous Pathology · 年份：2021 · DOI：10.1111/cup.13974 · 被引用次数：6 · 研究领域：Cutaneous lymphoproliferative disorders research、Lymphoma Diagnosis and Treatment、Autoimmune Bullous Skin Diseases

Lymphomatoid papulosis (LyP) type E is a rare variant of the primary cutaneous CD30+ lymphoproliferative disorders, characterized clinically by large necrotic eschar-like lesions and histopathologically by angiodestructive and angioinvasive infiltrates of CD30+ lymphocytes. As in other forms of lymphomatoid papulosis, type E lesions may undergo spontaneous regression after weeks, with frequent recurrences. We report a 21-year old male with an angiodestructive infiltrate of CD30+ lymphocytes manifesting as a papular eruption rather than ulceration, and suggest that this clinical phenotype might be related to the presence of CD4+ lymphocytes in the inflammatory cell infiltrate.