Urchin-Shaped Metal Organic/Hydrogen-Bonded Framework Nanocomposite as a Multifunctional Nanoreactor for Catalysis-Enhanced Synergetic Therapy

作者：Chunling Hu, Jiazhi Wang, Sainan Liu, Lihan Cai, Ying Zhou, Xiangjian Liu, Man Wang, Zhendong Liu, Maolin Pang · 发表于：ACS Applied Materials & Interfaces · 年份：2021 · DOI：10.1021/acsami.0c19584 · 被引用次数：69 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Luminescence and Fluorescent Materials

Ultrasound (US)-induced sonodynamic therapy (SDT) is an efficient and precise method against tumor, and the integration of multiple cancer therapies has been proved as a promising strategy for better therapeutic effects. Herein, for the first time, a multifunctional nanoreactor has been fabricated by integrating Fe–MIL-88B–NH 2, PFC-1, and glucose oxidase (GO x ) to form urchin-like Fe–MIL-88B–NH 2 @PFC-1-GO x (MPG) nanoparticles as Fenton’s reagent, a sonosensitizer, and a tumor microenvironment (TME) modulator. In detail, MPG can generate • OH for chemodynamic therapy (CDT) and deplete glutathione (GSH) to alleviate the antioxidant ability of cancer cells. Moreover, catalase (CAT)-like MPG can react with H 2 O 2 to generate O 2 for relieving hypoxia in TME, enhancing GO x -catalyzed glucose oxidation to produce H 2 O 2 and gluconic acid. Then, the regenerated H 2 O 2 can promote the Fenton reaction to achieve GO x catalysis-enhanced CDT. Owing to its large π-electron conjugated system, MPG also serves as an ideal sonosensitizer, realizing a burst generation of 1 O 2 under US irradiation for efficient SDT. Therefore, the tumor treatment will be notably enhanced by MPG-based synergetic CDT/SDT/starvation therapy via a series of cascade reactions. Overall, this work develops a versatile nanoreactor with improved tumor treatment effectiveness and broadens the application prospects of porous materials in the field of biomedical research.