5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium

作者：Stephanie A. Cevallos, Jee‐Yon Lee, Eric M. Velazquez, Nora J. Foegeding, Catherine Shelton, Connor R. Tiffany, Beau H. Parry, Annica R. Stull-Lane, Erin E. Olsan, Hannah P. Savage, Henry Nguyen, Star S. Ghanaat, Austin J. Byndloss, Ilechukwu Agu, Renée M. Tsolis, Mariana X. Byndloss, Andreas J. Bäumler · 发表于：mBio · 年份：2021 · DOI：10.1128/mbio.03227-20 · 被引用次数：136 · 研究领域：Gut microbiota and health、Helicobacter pylori-related gastroenterology studies、Clostridium difficile and Clostridium perfringens research

An expansion of Enterobacterales in the fecal microbiota is a microbial signature of dysbiosis that is linked to many noncommunicable diseases, including ulcerative colitis. Here, we used Escherichia coli , a representative of the Enterobacterales , to show that its dysbiotic expansion during colitis can be remediated by modulating host epithelial metabolism.