Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice

作者：Inmaculada López‐Almela, Marina Romaní‐Pérez, Clara Bullich‐Vilarrubias, Alfonso Benítez‐Páez, Eva M. Gómez del Pulgar, Rubén Francés, Gerhard Liebisch, Yolanda Sanz · 发表于：Gut Microbes · 年份：2021 · DOI：10.1080/19490976.2020.1865706 · 被引用次数：166 · 研究领域：Gut microbiota and health、Exercise and Physiological Responses、Dietary Effects on Health

Gut microbiota represents a therapeutic target for obesity. We hypothesize that B. uniformis CECT 7771 combined with wheat bran extract (WBE), its preferred carbon source, may exert superior anti-obesity effects. We performed a 17-week intervention in diet-induced obese mice receiving either B. uniformis, WBE, or their combination to identify interactions and independent actions on metabolism and immunity. B. uniformis combined with WBE was the most effective intervention, curbing weight gain and adiposity, while exerting more modest effects separately. The combination restored insulin-dependent metabolic routes in fat and liver, although the bacterium was the primary driver for improving whole-body glucose disposal. Moreover, B. uniformis-combined with WBE caused the highest increases in butyrate and restored the proportion of induced intraepithelial lymphocytes and type-3 innate lymphoid cells in the intestinal epithelium. Thus, strengthening the first line of immune defense against unhealthy diets and associated dysbiosis in the intestine. This intervention also attenuated the altered IL22 signaling and liver inflammation. Our study shows opportunities for employing B. uniformis, combined with WBE, to aid in the treatment of obesity.