The importance of modeling the human cerebral vasculature in blunt trauma

作者：Dhananjay Radhakrishnan Subramaniam, Ginu Unnikrishnan, Aravind Sundaramurthy, Jose E. Rubio, Vivek Bhaskar Kote, Jaques Reifman · 发表于：BioMedical Engineering OnLine · 年份：2021 · DOI：10.1186/s12938-021-00847-x · 被引用次数：18 · 研究领域：Automotive and Human Injury Biomechanics、Traumatic Brain Injury and Neurovascular Disturbances、Traumatic Brain Injury Research

BACKGROUND: Multiple studies describing human head finite element (FE) models have established the importance of including the major cerebral vasculature to improve the accuracy of the model predictions. However, a more detailed network of cerebral vasculature, including the major veins and arteries as well as their branch vessels, can further enhance the model-predicted biomechanical responses and help identify correlates to observed blunt-induced brain injury. METHODS: We used an anatomically accurate three-dimensional geometry of a 50th percentile U.S. male head that included the skin, eyes, sinuses, spine, skull, brain, meninges, and a detailed network of cerebral vasculature to develop a high-fidelity model. We performed blunt trauma simulations and determined the intracranial pressure (ICP), the relative displacement (RD), the von Mises stress, and the maximum principal strain. We validated our detailed-vasculature model by comparing the model-predicted ICP and RD values with experimental measurements. To quantify the influence of including a more comprehensive network of brain vessels, we compared the biomechanical responses of our detailed-vasculature model with those of a reduced-vasculature model and a no-vasculature model. RESULTS: For an inclined frontal impact, the predicted ICP matched well with the experimental results in the fossa, frontal, parietal, and occipital lobes, with peak-pressure differences ranging from 2.4% to 9.4%. For a normal frontal impact, the...