Immunosenescence Study of T Cells: A Systematic Review

作者：Ivón Johanna Rodríguez, Nicolás Lalinde Ruiz, Manuela Llano León, Laura Martinez, María del Pilar Montilla Velásquez, Juan Pablo Ortiz Aguirre, Oscar Mauricio Rodríguez Bohórquez, Esteban Alejandro Velandia Vargas, Edgar Debray Hernández-Álvarez, Carlos Alberto Parra López · 发表于：Frontiers in Immunology · 年份：2021 · DOI：10.3389/fimmu.2020.604591 · 被引用次数：224 · 研究领域：Telomeres, Telomerase, and Senescence、Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Single-cell and spatial transcriptomics

Background: Aging is accompanied by alterations in immune response which leads to increased susceptibility to infectious diseases, cancer, autoimmunity, and inflammatory disorders. This decline in immune function is termed as immunosenescence; however, the mechanisms are not fully elucidated. Experimental approaches of adaptive immunity, particularly for T cells, have been the main focus of immunosenescence research. This systematic review evaluates and discusses T cell markers implicated in immunosenescence. Objective: To determine the best flow cytometry markers of circulating T cells associated with immunosenescence. Methods: We systematically queried PubMed, MEDLINE, EBSCO, and BVS databases for original articles focused on two age groups of healthy humans: 18-44 (young adults) and >60 (older adults) years. In accordance with the Cochrane methodology, we synthesized data through qualitative descriptions and quantitative random effects meta-analysis due to extensive heterogeneity. Results: A total of 36 studies conducted in the last 20 years were included for the qualitative analysis and four out of these studies were used to perform the meta-analysis. A significant decrease in naïve T cell subset was observed in older adults compared to young adults. Primary markers used to identify senescent cells were loss of CD28 and increased expression of CD57 and KLRG1 in terminally-differentiated memory T cell subset in older adults. Moreover, we observed an increase in proinflamma...