ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL‐2 Pathway

作者：Xiaohui Pan, Jingxue Tan, Xiaokun Weng, Rui Du, Yuqing Jiang, Yiping Weng, Dong Zhou, Yifei Shen · 发表于：BioMed Research International · 年份：2021 · DOI：10.1155/2021/8971728 · 被引用次数：6 · 研究领域：Cytokine Signaling Pathways and Interactions、Cancer Mechanisms and Therapy、FOXO transcription factor regulation

Osteosarcoma (OS) is a familiar malignant bone tumor that occurs mainly in adolescents. Immature colon carcinoma transcript-1 (ICT1) is an important member of the large mitoribosomal subunit in mitochondrial ribosomes, which has been shown to be closely related to tumorigenesis. Its expression and function in OS, however, remained unclear. Here, we showed that ICT1 was significantly upregulated in OS and promoted the growth of OS cells. Mechanistically, ICT1 acted as an oncogene in OS and promoted proliferation and inhibited apoptosis of OS cells through the STAT3/BCL-2 axis. These results reveal a novel insight into the role of the ICT1/STAT3/BCL-2 axis in OS and therefore may represent a novel molecular target for novel treatments.