Characteristics of human immunodeficiency virus exposure and predictors of time until access to postexposure prophylaxis: a prospective observational study

作者：Enrique Casalino, Donia Bouzid, Stéphanie Antoniol, Adriana Pinto, Christophe Choquet, Laurent Pereira, Thomas Pavlovsky, Vittiaroat Ing, Yazdan Yazdanpanah, Jade Ghosn, Daniel Aiham Ghazali · 发表于：Emergencias · 年份：2025 · DOI：10.55633/s3me/110.2021 · 被引用次数：5 · 研究领域：HIV/AIDS Research and Interventions、Infection Control in Healthcare、Sex work and related issues

OBJECTIVES: The efficacy of postexposure prophylaxis (PEP) after human immunodeficiency virus (HIV) contact relies on administering the treatment within 4 hours of contact with the virus. This study aimed to evaluate predictors of the time that elapses between HIV exposure and emergency department arrival. MATERIAL AND METHODS: Prospective observational study carried out at Hôpital Bichat, a university teaching hospital in Paris, France. All emergency visits for occupational or nonoccupational exposure to HIV in 2016 and 2017 were included. RESULTS: A total of 1475 cases were studied; 598 patients responded to the follow-up survey. A delay of 4 hours or more between HIV exposure and the emergency department visit was associated with type of contact: health care occupational exposure, other occupational exposure, or sexual intercourse (P .001). We found significant differences between individuals exposed during sexual contact versus occupational exposure with respect to knowledge of the PEP program pathway (65.2% vs 46.9%, respectively), previous use of PEP (23.9% vs 13.1%), alcohol intake (36.2% vs 18.5%), drug use (34.6% vs 8.6%), and chemsex (sexualized drug use) (26.1% vs 0%) (P .001, all comparisons). Predictors of time until start of PEP among individuals exposed during sexual intercourse were knowledge and prior use of the PEP pathway (P .001), drug use (P = .03), and chemsex (P .001). Predictors among occupationally exposed individuals were prior knowledge of the PEP p...