Interim Effectiveness and Safety Comparison of Bedaquiline-Containing Regimens for Treatment of Diabetic Versus Non-Diabetic MDR/XDR-TB Patients in China: A Multicenter Retrospective Cohort Study

作者：Shi Li, Jingtao Gao, Mengqiu Gao, Ping Deng, Shu Chen, Minfu He, Wenjun Feng, Yang Xiao-yun, Yunhui Huang, Fang He, Yumeng Hu, Liping Lei, Xuelian Li, Juan Du, Xiaomeng Hu, Zhi Liu, Peijun Tang, Junfeng Han, Hua Wang, Yi Han, Wei Shu, Yuxian Sun, Yi Pei, Yuhong Liu · 发表于：Infectious Diseases and Therapy · 年份：2021 · DOI：10.1007/s40121-021-00396-9 · 被引用次数：30 · 研究领域：Tuberculosis Research and Epidemiology、Diagnosis and treatment of tuberculosis、Mangiferin and Mango Extracts

INTRODUCTION: Diabetes mellitus (DM), a common tuberculosis (TB) comorbidity, is associated with delayed bacillary clearance during anti-TB treatment and unfavorable outcomes. Bedaquiline (BDQ), when used as part of multidrug regimen for multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB), has been shown to be effective and safe although treatment outcome and risks for patients with MDR/XDR-TB and DM are unknown. A multicenter retrospective study was conducted to compared the safety and effectiveness of 24-week BDQ-containing anti-TB treatment for patients with MDR/XDR-TB with and without DM. METHODS: The study of patients with MDR/XDR-TB with or without DM (enrolled February 2018-September 2019, 21 Chinese hospitals) was supervised by the New Drug Introduction and Protection Program (NDIP). Of 640 patients with MDR/XDR-TB receiving BDQ-containing anti-TB treatments, two propensity score-matched groups (107 DM/107 non-DM) were compared for cumulative culture conversion rate, time to culture conversion, adverse events, and corrected QT interval. RESULTS: Body mass index was higher in patients with DM than patients without DM (23.29 ± 3.9 vs. 20.5 ± 3.6, P < 0.001); lung cavity prevalence (86.9% vs. 72.9%, P = 0.037) was also higher in patients with DM; the non-DM group had higher hepatitis prevalence (29.0% vs. 15.9%, P = 0.022). No significant intergroup differences were found for sputum culture conversion rate at week 8 (80.0% vs. 81.4%, P = 0.884), at w...