Engineering a Smart Nanofluidic Sensor for High-Performance Peroxynitrite Sensing through a Spirocyclic Ring Open/Close Reaction Strategy

作者：Yangyan Li, Le Tuan Tu, Xin Ma, Huan Chen, Yifan Fan, Qiang Zhou, Yao Sun · 发表于：ACS Sensors · 年份：2021 · DOI：10.1021/acssensors.0c01719 · 被引用次数：26 · 研究领域：Electrochemical sensors and biosensors、Analytical Chemistry and Sensors、Molecular Sensors and Ion Detection

Peroxynitrite (ONOO – ) is an important reactive oxygen/nitrogen species that participates in a range of physiological and pathological processes by modulating ion flux through biological channels. Inspired by a ONOO – -regulated K + channel in vivo, herein, we describe the construction of a smart ONOO – -driven nanosensor using a spirocyclic ring open/close reaction approach. The prepared nanosensor possessed a prominent ONOO – selectivity and sensitivity and rapid response (∼90 s) owing to the specific reaction between ONOO – and ligands on the nanosensor surface with a high ion rectification ratio (∼10) and ion gating ratio (∼4). Moreover, this nanosensor system also exhibits excellent stability and recyclability. Thus, these results will provide a new direction for the design of nanochannel-based sensors for future practical and biological applications.