Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart

作者：Raihan Kabir, Prithvi Sinha, Sumita Mishra, Obialunanma V. Ebenebe, Nicole Taube, Christian U. Oeing, Gizem Keceli, Rui Chen, Nazareno Paolocci, Ana M. Rule, Mark J. Kohr · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2021 · DOI：10.1152/ajpheart.00435.2020 · 被引用次数：30 · 研究领域：Arsenic contamination and mitigation、Heavy Metal Exposure and Toxicity、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

This investigation provides the first mechanistic link between an environmentally relevant dose of inorganic arsenic (iAS) and pathological hypertrophy in the heart. By demonstrating that iAS exposure may cause pathological cardiac hypertrophy not only by increasing systolic blood pressure but also by potentially activating calcineurin-nuclear factor of activated T cells and inducing fetal gene expression, these results provide novel mechanistic insight into the theat of iAS exposure to the heart, which is necessary to identify targets for medical and public health intervention.