Peripheral immune markers and antipsychotic non-response in psychosis

作者：Daniela Enache, Naghmeh Nikkheslat, Dina Fathalla, B. Paul Morgan, Shôn Lewis, Richard Drake, J.F.W. Deakin, James Walters, Stephen M. Lawrie, Alice Egerton, James H. MacCabe, Valeria Mondelli · 发表于：Schizophrenia Research · 年份：2021 · DOI：10.1016/j.schres.2020.12.020 · 被引用次数：68 · 研究领域：Tryptophan and brain disorders、Schizophrenia research and treatment、Bipolar Disorder and Treatment

BACKGROUND: Peripheral immune markers have previously been linked to a poor response to antipsychotic medication and more severe negative symptoms at the onset of psychosis. The present study investigated the association of blood cytokines and complement markers with the presence of antipsychotic non-response and symptom severity in patients with psychosis. METHODS: This cross-sectional study recruited 94 patients with schizophrenia and other psychoses, of whom 47 were defined as antipsychotic responders and 47 as antipsychotic non-responders. In all subjects we measured plasma levels of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α, and IFN-γ), complement markers (C1-inhibitor, C3, C4, C3a, C3b, Bb, factor D, C5a, terminal complement complex) and high sensitivity C-reactive protein (hsCRP). Symptom severity was recorded using the Positive and Negative Syndrome scale for Schizophrenia (PANSS). Binary logistic regression tested each immune marker as predictor of response status while covarying for relevant socio-demographic variables. Correlation analyses tested the association between immune markers and the severity of symptoms. RESULTS: Interleukin (IL)-8 significantly predicted antipsychotic non-response (OR=24.70, 95% CI, 1.35-453.23, p = 0.03). Other immune markers were not associated with antipsychotic response. IL-6, IL-8, IL-10 and TNF-α significantly positively correlated with negative psychotic symptoms. CONCLUSIONS: Higher levels of IL-8 ar...