TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses

作者：Yanran Xu, Cao‐Qi Lei · 发表于：Frontiers in Immunology · 年份：2021 · DOI：10.3389/fimmu.2020.608976 · 被引用次数：241 · 研究领域：NF-κB Signaling Pathways、Immune Response and Inflammation、interferon and immune responses

Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding proteins (TAB1, TAB2, and TAB3) and can be activated by a variety of stimuli such as tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and toll-like receptor ligands, and they play essential roles in the activation of NF-κB and MAPKs. Numerous studies have demonstrated that post-translational modifications play important roles in properly controlling the activity, stability, and assembly of TAK1-TABs complex according to the indicated cellular environment. This review focuses on the recent advances in TAK1-TABs-mediated signaling and the regulations of TAK1-TABs complex by post-translational modifications.