CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3

作者：Weibo Feng, Wenjie Huang, Jie Chen, Chenyang Qiao, Danfei Liu, Xiaoyu Ji, Meng Xie, Tongyue Zhang, Yi‐Jun Wang, Mengyu Sun, Dean Tian, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia · 发表于：Theranostics · 年份：2021 · DOI：10.7150/thno.52199 · 被引用次数：71 · 研究领域：Chemokine receptors and signaling、interferon and immune responses、Cell Adhesion Molecules Research

Our study implicates HOXB5 as a prognostic biomarker in CRC, and defines a CXCL12-HOXB5-CXCR4 positive feedback loop that plays an important role in promoting CRC metastasis.