Prognostic significance of serum inflammation indexes in different Lauren classification of gastric cancer

作者：Xin Yin, Tianyi Fang, Yimin Wang, Yufei Wang, Daoxu Zhang, Chunfeng Li, Yingwei Xue · 发表于：Cancer Medicine · 年份：2021 · DOI：10.1002/cam4.3706 · 被引用次数：19 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Gastric Cancer Management and Outcomes、Metastasis and carcinoma case studies

BACKGROUND: Inflammatory indexes are considered to be potential prognostic biomarkers for patients with gastric cancer (GC). However, little evidence has defined the prognostic significance of inflammatory indexes for GC with different Lauren classification. METHODS: A total of 852 patients with GC were randomly selected consecutively into intestinal type and diffuse/mixed type groups. Group bias was reduced by propensity score matching. The cutoff values of inflammatory indexes were analyzed by receiver operating characteristic curve. The Kaplan-Meier method and log-rank test were used to analyze the overall survival (OS). The chi-square test was used to analyze the association between inflammatory indexes and clinical characteristics. The independent risk factor for prognosis in each group was analyzed by univariate and multivariate analyses based on logistic regression. The nomogram models were constructed by R studio. RESULTS: Intestinal type GC patients (p < 0.05) had a lower percentage of neutrophils in stage I, higher percentage of neutrophils and higher platelet count in stage Ⅲ (p < 0.05). Systemic immune-inflammation index (SII) (p < 0.001), pTNM stage (p < 0.001), and postoperative chemotherapy (p = 0.002) were independent risk factors for prognosis in the intestinal type group. Platelet-lymphocyte ratio (PLR) (p < 0.001) and pTNM stage (p = 0.001) were independent risk factors for prognosis in the diffuse/mixed type group. The area under the curve of the nomogram ...