Recurrent dissemination of SARS-CoV-2 through the Uruguayan-Brazilian border

作者：Daiana Mir, Natalia Rego, Paola Cristina Resende, Luis Fernando López Tort, Tamara Fernández-Calero, Verónica Noya, Mariana Brandes, Tania Possi, Mailén Arleo, Natalia Reyes, Matías Victoria, Andrés Lizasoain, Matías Castells, Leticia Maya, Matías Salvo, Tatiana Schäffer Gregianini, Marilda Tereza Mar da Rosa, Letícia Garay Martins, Cecília Alonso, Yasser Vega, Cecilia Salazar, Ignacio Ferrés, Pablo Smircich, J. Roberto Sotelo, Rafael Sebastián Fort, Cecilia Mathó, Ighor Arantes, Luciana Appolinario, Ana Carolina da Fonseca Mendonça, María José Benítez-Galeano, Martín Graña, Camila Simoes, Fernando Couto Motta, Marilda Mendonça Siqueira, Gonzalo Bello, Rodney Colina, Lucía Spangenberg · 发表于：medRxiv · 年份：2021 · DOI：10.1101/2021.01.06.20249026 · 被引用次数：12 · 研究领域：SARS-CoV-2 and COVID-19 Research、Virology and Viral Diseases、SARS-CoV-2 detection and testing

Summary Background Uruguay is one of the few countries in the Americas that successfully contained the COVID-19 epidemic during the first half of 2020. Nevertheless, the intensive human mobility across the dry border with Brazil is a major challenge for public health authorities. We aimed to investigate the origin of SARS-CoV-2 strains detected in Uruguayan localities bordering Brazil as well as to measure the viral flux across this ∼1,100 km uninterrupted dry frontier. Methods Using complete SARS-CoV-2 genomes from the Uruguayan-Brazilian bordering region and phylogeographic analyses, we inferred the virus dissemination frequency between Brazil and Uruguay and characterized local outbreak dynamics during the first months (May-July) of the pandemic. Findings Phylogenetic analyses revealed multiple introductions of SARS-CoV-2 Brazilian lineages B.1.1.28 and B.1.1.33 into Uruguayan localities at the bordering region. The most probable sources of viral strains introduced to Uruguay were the Southeast Brazilian region and the state of Rio Grande do Sul. Some of the viral strains introduced in Uruguayan border localities between early May and mid-July were able to locally spread and originated the first outbreaks detected outside the metropolitan region. The viral lineages responsible for Uruguayan suburban outbreaks were defined by a set of between four and 11 mutations (synonymous and non-synonymous) respect to the ancestral B.1.1.28 and B.1.1.33 viruses that arose in Brazil, su...