[Analysis of the clinical features and the risk factors of severe adenovirus pneumonia in children].

作者：Han Huang, Yu Chen, Lv Y., Michael Yan, Ye Deng, Wen Zhang, Y Yuan, P Xiong, F Fang, T L Liu · 发表于：PubMed · 年份：2021 · DOI：10.3760/cma.j.cn112140-20200704-00687 · 被引用次数：19 · 研究领域：Virus-based gene therapy research、Biomedical and Engineering Education、Cancer Research and Treatments

The mortality rate of severe pediatric adenovirus pneumonia caused by adenovirus type 7 is high. High positive rates of adenovirus nucleic acid in nasopharyngeal swabs and mNGS in plasma or bronchoalveolar lavage fluid contribute to early diagnosis, and mNGS can also be used for serotyping. Younger children under 4 years of age, persistent fever, extensive pulmonary lesions and significantly increased inflammatory cytokines such as IL-6 are warning indicators for critical illness and poor prognosis. Relatively high dose of ribavirin combined with integrated therapeutic approaches are beneficial for prognosis.