Uniportal Versus Multiportal Video-Assisted Thoracoscopic Lobectomy for Lung Cancer: An Updated Meta-analysis

作者：Dimitrios E. Magouliotis, Maria P. Fergadi, Kyriakos Spiliopoulos, Kalliopi Athanassiadi · 发表于：Lung · 年份：2021 · DOI：10.1007/s00408-020-00411-9 · 被引用次数：55 · 研究领域：Lung Cancer Diagnosis and Treatment、Pleural and Pulmonary Diseases、Tracheal and airway disorders

Abstract Objective We reviewed the available literature on patients with lung cancer undergoing either uniportal (UVATS) or multiport video-assisted thoracoscopic surgery (MVATS). Methods Original research studies that evaluated perioperative and long-term outcomes of UVATS versus MVATS were identified, from January 1990 to April 2020. The perioperative, along with the oncologic and long-term survival outcomes, were calculated according to either a fixed or a random effect model, appropriately. The Q statistics and I 2 statistic were used to test for heterogeneity among the studies. Results Twenty studies were included, incorporating a total of 1,469 patients treated with UVATS and 3,231 treated with MVATS. The incidence of complications was lower in patients treated with UVATS [OR: 0.76 (95% CI 0.62, 0.93); p = 0.008]. The chest tube duration was significantly lower in the UVATS group (WMD: − 0.63 [95% CI − 1.03, − 0.23]; p = 0.002). Length of hospital stay (L.O.S.) was also lower in the UVATS patient group (WMD: − 0.54 [− 0.94, − 0.13]; p = 0.009), along with postoperative pain [WMD: − 0.57 (95% CI − 0.97, − 0.18); p = 0.004]. No significant differences were found regarding the mean operative time (M.O.T.), mean blood loss, the number of resected lymph nodes, the 30-day mortality, along with the survival at 1 and 3 years postoperatively. Conclusions The present meta-analysis indicates that UVATS is associated with enhanced outcomes in patients undergoing surgery for lung ca...