Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

作者：Fen Nie, Junyi Ouyang, Wenquan Tang, Lijia Luo, Mengdan Cao, Lurong Zhang, Dengming Zhou, Ke Liu, Daijin Ma, Xuanchu Duan · 发表于：Graefe s Archive for Clinical and Experimental Ophthalmology · 年份：2021 · DOI：10.1007/s00417-020-05057-0 · 被引用次数：17 · 研究领域：Retinal and Macular Surgery、Glaucoma and retinal disorders、Ocular Oncology and Treatments

OBJECTIVE: To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). METHODS: This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters. RESULTS: The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, P < 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, P = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, P = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, P = 0.003) and angle α between temporal retinal arterial vascular arcades (113.29°vs 128.39°, P = 0.003), a larger disc tilt ratio (1.41 vs 1.24, P < 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, P = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (P = 0.031) and SFCT (P = 0.015) were significant pre...