Immune Cell–Stromal Circuitry in Lupus Photosensitivity

作者：Ji Hyun Sim, William G Ambler, Isabel F Sollohub, Mir J Howlader, Thomas M. Li, Henry J. Lee, Theresa T. Lu · 发表于：The Journal of Immunology · 年份：2021 · DOI：10.4049/jimmunol.2000905 · 被引用次数：26 · 研究领域：Systemic Lupus Erythematosus Research、T-cell and B-cell Immunology、Immune Cell Function and Interaction

Photosensitivity is a sensitivity to UV radiation (UVR) commonly found in systemic lupus erythematosus (SLE) patients who have cutaneous disease. Upon even ambient UVR exposure, patients can develop inflammatory skin lesions that can reduce the quality of life. Additionally, UVR-exposed skin lesions can be associated with systemic disease flares marked by rising autoantibody titers and worsening kidney disease. Why SLE patients are photosensitive and how skin sensitivity leads to systemic disease flares are not well understood, and treatment options are limited. In recent years, the importance of immune cell-stromal interactions in tissue function and maintenance is being increasingly recognized. In this review, we discuss SLE as an anatomic circuit and review recent findings in the pathogenesis of photosensitivity with a focus on immune cell-stromal circuitry in tissue health and disease.