Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

作者：Wen Xu, Changfeng Song, Xiaotong Wang, Yueqi Li, Xue Bai, Xin Liang, Jingjing Wu, Jianwen Liu · 发表于：Aging · 年份：2021 · DOI：10.18632/aging.103669 · 被引用次数：73 · 研究领域：Inflammasome and immune disorders、Circular RNAs in diseases、Gout, Hyperuricemia, Uric Acid

experiments confirmed that the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in an MDA-MB-468 xenograft model and on EGFR-overexpressed TNBC cells via inducing cell apoptosis and pyroptosis. Therefore, cetuximab combination with an miR-155-5p antagomir may be a novel therapeutic strategy for the treatment of TNBC.