Recent advances in chemistry and bioactivity of Sargentodoxa cuneata

作者：Wen Zhang, Cheng‐Peng Sun, Shuang Zhou, Wen‐Yu Zhao, Lin Wang, Lingli Sheng, Jing Yi, Tiantian Liu, Juanjuan Yan, Xiaochi Ma, Bangjiang Fang · 发表于：Journal of Ethnopharmacology · 年份：2021 · DOI：10.1016/j.jep.2021.113840 · 被引用次数：33 · 研究领域：Phytochemistry and Biological Activities、Biological Activity of Diterpenoids and Biflavonoids、Natural product bioactivities and synthesis

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Sargentodoxa comprises only one species, Sargentodoxa cuneata (Oliv.) Rehd et al., widely distributed in the subtropical zone of China. The plant is extensively used in traditional medicine for treating arthritis, joint pains, amenorrhea, acute appendicitis and inflammatory intestinal obstruction. Pharmacological studies show anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-sepsis activities. AIM OF THE REVIEW: This review aims to summarize the information about distribution, traditional uses, chemical constituents and pharmacological activities of S. cuneata, as an attempt to provide a scientific basis for its traditional uses and to support its application and development for new drug development. METHODOLOGY: Scientific information of S. cuneata was retrieved from the online bibliographic databases, including Web of Science, Google Scholar, PubMed, Springer Link, the Wiley online library, SciFinder, Baidu Scholar, China national knowledge infrastructure (CNKI) and WANFANG DATA (up to March 2020). We also search doctoral dissertations, master dissertations conference papers and published books. The keywords were used: "Sargentodoxa", "Da Xue Teng", "Hong Teng", "Xue Teng", "secondary metabolites", "chemical components", "biological activity", "pharmacology", "traditional uses". OBSERVATIONS AND RESULTS: S. cuneata is utilized as valuable herbal medicines to treat various diseases in China. Over 110 chemical constit...