Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis

作者：Wei‐Wei Haoyang, Qi Xiao, Zhongju Ye, Yonghong Fu, Dan‐Wei Zhang, Jian Li, Lehui Xiao, Zhan‐Ting Li, Jun‐Li Hou · 发表于：Chemical Communications · 年份：2021 · DOI：10.1039/d0cc08073j · 被引用次数：29 · 研究领域：Ion channel regulation and function、Mass Spectrometry Techniques and Applications、Molecular Sensors and Ion Detection

A series of glycoside-peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose-asialoglycoprotein receptor recognition.