Effects of extracellular vesicles from mesenchymal stem cells on oxygen-glucose deprivation/reperfusion-induced neuronal injury

作者：Shuangshuang Gu, Xiuwen Kang, Jun Wang, Xiaofang Guo, Hao Sun, Lei Jiang, Jin-song Zhang · 发表于：World Journal of Emergency Medicine · 年份：2020 · DOI：10.5847/wjem.j.1920-8642.2021.01.010 · 被引用次数：15 · 研究领域：Extracellular vesicles in disease、MicroRNA in disease regulation、Neuroinflammation and Neurodegeneration Mechanisms

BACKGROUND: Small extracellular vesicles (sEVs) from bone marrow mesenchymal stem cells (BMSCs) have shown therapeutic potential for cerebral ischemic diseases. However, the mechanisms by which BMSC-derived sEVs (BMSC-sEVs) protect neurons against cerebral ischemia/reperfusion (I/R) injury remain unclear. In this study, we explored the neuroprotective effects of BMSC-sEVs in the primary culture of rat cortical neurons exposed to oxygen-glucose deprivation and reperfusion (OGD/R) injury. METHODS: . Based on this model, we examined whether the mechanism through which BMSC-sEVs could rescue OGD/R-induced neuronal injury. RESULTS: ) caused by OGD/R in neurons. CONCLUSIONS: /CaMK II signaling pathways may be involved in this process.