Effect of Rosuvastatin Therapy on Biomarkers of Inflammation and Immune Activation in People With Human Immunodeficiency Virus at Intermediate Cardiovascular Risk

作者：Anna C. Hearps, Thomas A. Angelovich, Janine M. Trevillyan, Michelle E. Wong, Alexandra Calmy, Jennifer Hoy, Anthony Jaworowski · 发表于：The Journal of Infectious Diseases · 年份：2020 · DOI：10.1093/infdis/jiaa775 · 被引用次数：13 · 研究领域：HIV-related health complications and treatments、Lipoproteins and Cardiovascular Health、HIV Research and Treatment

BACKGROUND: Statins may help prevent cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH) with chronic inflammation owing to their pleotropic lipid-lowering and anti-inflammatory properties. METHODS: The impact of 48 weeks of rosuvastatin therapy on inflammation and immune activation in a double-blind, placebo-controlled trial in PWH at moderate cardiovascular disease risk was assessed. RESULTS: Rosuvastatin did not alter plasma levels of interleukin 6, soluble tumor necrosis factor receptor type 2, CXCL10, soluble CD14, or soluble vascular cellular adhesion molecule 1 (P ≥ .1 for all). Proportions of CD16+ monocyte subsets were increased in PWH receiving rosuvastatin. CONCLUSIONS: The potential benefits of statin use in PWH with normal lipid levels requires further clinical outcome research.