Anti-Inflammatory and Gastroprotective Effects of Escin

作者：Yunqi Yang, Linlin Wang, Man Yuan, Yu Qi, Fenghua Fu · 发表于：Natural Product Communications · 年份：2020 · DOI：10.1177/1934578x20982111 · 被引用次数：25 · 研究领域：Sphingolipid Metabolism and Signaling、Phytochemical Studies and Bioactivities、Natural product bioactivities and synthesis

Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsonii Rehd. and Aesculus hippocastanum (Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the effects of escin on inflammation and gastrointestinal diseases, including its role in inflammation, as an antioxidant, and in inhibiting gastric acid secretion and promoting gastrointestinal movement, especially, the molecular mechanism. The advantages and potential uses of escin have also been discussed.