microRNA-219-5p targets NEK6 to inhibit hepatocellular carcinoma progression.

作者：Gong Ting, Xin Li, Hyog Young Kwon, Tengteng Ding, Zhihao Zhang, Zhugui Chen, Chenglin Li, Youtan Liu, Yinggui Yang · 发表于：PubMed · 年份：2020 · 被引用次数：14 · 研究领域：Cancer Genomics and Diagnostics、Ferroptosis and cancer prognosis、RNA modifications and cancer

. Bioinformatics analyses were also conducted, and both miR-219-5p and Nek6 were linked to disease progression in HCC patients with advanced disease. More importantly, the serum specimen data showed that reduced perioperative plasma miR-219-5p correlated significantly with increased risk of early recurrence after curative hepatectomy, whereas it was opposed to NEK6. Together, these findings highlight miR-219-5p as a potentially valuable diagnostic biomarker that can potentially be leveraged to improve clinical outcomes in HCC patients.