Abnormal dorsal attention network activation in memory impairment after traumatic brain injury

作者：Emma‐Jane Mallas, Sara De Simoni, Gregory Scott, Amy Jolly, Adam Hampshire, Lucia M. Li, Niall Bourke, Stuart Roberts, Nikos Gorgoraptis, David Sharp · 发表于：Brain · 年份：2020 · DOI：10.1093/brain/awaa380 · 被引用次数：42 · 研究领域：Functional Brain Connectivity Studies、EEG and Brain-Computer Interfaces、Traumatic Brain Injury Research

Memory impairment is a common, disabling effect of traumatic brain injury. In healthy individuals, successful memory encoding is associated with activation of the dorsal attention network as well as suppression of the default mode network. Here, in traumatic brain injury patients we examined whether: (i) impairments in memory encoding are associated with abnormal brain activation in these networks; (ii) whether changes in this brain activity predict subsequent memory retrieval; and (iii) whether abnormal white matter integrity underpinning functional networks is associated with impaired subsequent memory. Thirty-five patients with moderate-severe traumatic brain injury aged 23-65 years (74% males) in the post-acute/chronic phase after injury and 16 healthy control subjects underwent functional MRI during performance of an abstract image memory encoding task. Diffusion tensor imaging was used to assess structural abnormalities across patient groups compared to 28 age-matched healthy controls. Successful memory encoding across all participants was associated with activation of the dorsal attention network, the ventral visual stream and medial temporal lobes. Decreased activation was seen in the default mode network. Patients with preserved episodic memory demonstrated increased activation in areas of the dorsal attention network. Patients with impaired memory showed increased left anterior prefrontal activity. White matter microstructure underpinning connectivity between core n...