Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

作者：Patrick Ostkamp, Anke Salmen, Béatrice Pignolet, Dennis Görlich, Till F. M. Andlauer, Andreas Schulte‐Mecklenbeck, Gabriel González‐Escamilla, Florence Bucciarelli, Isabelle Gennero, Johanna Breuer, Gisela Antony, Tilman Schneider‐Hohendorf, Nadine Mykicki, Antonios Bayas, Florian Then Bergh, Stefan Bittner, Hans‐Peter Hartung, Manuel Alexander Friese, Ralf Andreas Linker, Felix Luessi, Klaus Lehmann‐Horn, Mark Mühlau, Friedemann Paul, Martin Stangel, Björn Tackenberg, Hayrettin Tumani, Clemens Warnke, Frank Weber, Brigitte Wildemann, Uwe Klaus Zettl, Ulf Ziemann, Bertram Müller‐Myhsok, Tania Kümpfel, Luisa Klotz, Sven Guenther Meuth, Frauke Zipp, Bernhard Hemmer, Reinhard Hohlfeld, David Brassat, Ralf Gold, Catharina C. Groß, Carsten Lukas, Sergiu Groppa, Karin Loser, Heinz Wiendl, Nicholas Schwab, on behalf of the German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network, Antonios Bayas, Susanne Rothacher, Stephanie Starke, Friedemann Paul, Judith Bellmann–Strobl, Janina Ruth Behrens, Jan-Markus Dörr, René M. Gieß, Joseph Kuchling, Ludwig Rasche, Ralf Gold, Andrew Chan, Gisa Ellrichmann, Anna Lena Fisse, Anna Gahlen, Thomas Grüter, Aiden Haghikia, Robert Hoepner, U.-V. Koc, Carsten Lukas, Jeremias Motte, Kalliopi Pitarokoili, Anke Salmen, Ruth Schneider, Joanna Schöllhammer, Christoph Schroeder, Björn Ambrosius, Seray Demir, Clemens Warnke, Thomas Dehmel, Kathleen Ingenhoven, Ralf Andreas Linker, De-Hyung Lee, Alexandra Lämmer, Eva Sauer, Christoph Heesen, Jan‐Patrick Stellmann, Martin Stangel, Lena Boenig, Stefan Gingele, Martin W. Hümmert, Philipp Schwenkenbecher, Thomas Skripuletz, Wolfram Suehs, Brigitte Wildemann, Mirjam Korporal‐Kuhnke, Hanna Oßwald, Alexander Pavlovich Schwarz, Andrea Viehöver, Volker Limmroth, Kathrin Gerbershagen, Florian Then Bergh, Barbara Ettrich, Steffi Gray, Sarah Haars, Johannes Orthgieß, Nicole Schwanitz, Muriel Stoppe, Astrid Unterlauft, Sandra Paryjas, Stefan Bittner, Vinzenz Fleischer, Sergiu Groppa, Felix Lüssi, Johannes Piepgras, Timo Uphaus, Björn Tackenberg, Michael Pütz, Christian Eienbröker, Maria Seipelt, Reinhard Hohlfeld, Tania Kümpfel, Joachim B. Havla, Ingrid Meinl, Hannah Pellkofer, Elisabeth Schuh, Bernhard Hemmer, Lilian Aly, Achim Berthele, Viola Pongratz, Kirsten Brinkhoff, Dorothea Buck, Christiane Gasperi, Mirjam Hermisson, Muna‐Miriam Hoshi, Miriam Kaminski, Ana Paula Klein, Benjamin Knier, Markus Kowarik, Helena C. Kronsbein, K Horn, Meike Mitsdörffer, Verena Pernpeintner, Veit Rothhammer, Andrea Schweikert, Rebecca Selter, Mark Mühlau, Claus Zimmer, Jan Stefan Kirschke, Frank Weber, Heike Staufer, Matthias Knop, Sandra Nischwitz, Philipp Sämann, Heinz Wiendl, Sven Guenther Meuth, Luisa Klotz, Gerd Meyer zu Hörste, Julia Krämer, Lena Schünemann, Catharina C. Groß, Steffen Pfeuffer, Tobias Ruck, Selma Belgriri, Alexander Buchheister, Nora Bünger, Kerstin Göbel, Lucienne Kirstein, Nico Melzer, Ole J. Simon, Antje K. C. Echterhoff, Uwe Klaus Zettl, Alexander Winkelmann, Ulf Ziemann, Ahmed Abdelhak, Markus Kowarik, Markus Krumbholz, Margarete Paech, Christoph Ruschil, Maria‐Ioanna Stefanou, Johannes Tünnerhoff, Lena Zeltner, Hajera Sheikh, Hayrettin Tumani, Tanja Fangerau, Florian Lauda, Daniela Rau, Daniela Taranu, André M. Huss, David Brassat, Béatrice Pignolet, Florence Bucciarelli, Lise Scandella, Christine Lebrun‐Frénay, Marc Debouverie, S. Pittion‐Vouyovitch, Bruno Brochet, Aurélie Ruet, Gilles Louis Defer, Nathalie Derache, Jerome De Seze, David Axel Laplaud, Sandrine Wiertlewski, Oliver Casez, Pierre Clavelou, Pierre Labauge, J Pelletier, Audrey Rico, Sandra Vukusic, Olivier Outteryck, Jean-Claude, Jean‐Christophe Ouallet, Patrick Hautecoeur, Ayman Tourbah, Giovanni Castelnovo, Eric Berger, Hélène Zéphir, Philippe Cabre, William Camu, Éric Thouvenot, Thibault Moreau, Agnès Fromont, Caroline Papeix, Catherine Lubetzki, Patrick Vermersch, Mikaël Cohen, L. Rumbach · 发表于：Proceedings of the National Academy of Sciences · 年份：2020 · DOI：10.1073/pnas.2018457118 · 被引用次数：79 · 研究领域：Multiple Sclerosis Research Studies、Psoriasis: Treatment and Pathogenesis、Reproductive System and Pregnancy

:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.