Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19

作者：Song-Mao Ouyang, Hong-Quan Zhu, Ying-Na Xie, Zhi-Sheng Zou, Hui-Min Zuo, Yun-Wei Rao, Xiaoyan Liu, Bin Zhong, Xin Chen · 发表于：BMC Infectious Diseases · 年份：2020 · DOI：10.1186/s12879-020-05678-0 · 被引用次数：85 · 研究领域：COVID-19 Clinical Research Studies、Long-Term Effects of COVID-19、COVID-19 Impact on Reproduction

BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, and outbreaks have occurred worldwide. Laboratory test results are an important basis for clinicians to determine patient condition and formulate treatment plans. METHODS: Fifty-two thousand six hundred forty-four laboratory test results with continuous values of adult inpatients who were diagnosed with COVID-19 and hospitalized in the Fifth Hospital in Wuhan between 16 January 2020 and 18 March 2020 were compiled. The first and last test results were compared between survivors and non-survivors with variance test or Welch test. Laboratory test variables with significant differences were then included in the temporal change analysis. RESULTS: Among 94 laboratory test variables in 82 survivors and 25 non-survivors with COVID-19, white blood cell count, neutrophil count/percentage, mean platelet volume, platelet distribution width, platelet-large cell percentage, hypersensitive C-reactive protein, procalcitonin, D-dimer, fibrin (ogen) degradation product, middle fluorescent reticulocyte percentage, immature reticulocyte fraction, lactate dehydrogenase were significantly increased (P < 0.05), and lymphocyte count/percentage, monocyte percentage, eosinophil percentage, prothrombin activity, low fluorescent reticulocyte percentage, plasma carbon dioxide, total calcium, prealbumin, total protein, albumin, albumin-globulin ratio, cholinesterase, total cholesterol, nonhigh-de...