Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome

作者：Stephen Keddie, Julia Pakpoor, Christina Mousele, Menelaos Pipis, Pedro Machado, Mark Foster, Christopher J. Record, Ryan Keh, Janev Fehmi, Ross W. Paterson, Viraj Bharambe, Lisa M. Clayton, Claire Allen, Olivia Price, Jasmine Wall, Annamaria Kiss-Csenki, Devi Priya Rathnasabapathi, Ruth Geraldes, Tatyana Yermakova, Josh King‐Robson, Maya Zosmer, Sanjeev Rajakulendran, Sheetal Sumaria, Simon F. Farmer, Ross Nortley, Charles R. Marshall, Edward Newman, Niranjanan Nirmalananthan, Guru Kumar, Ashwin Pinto, James Holt, Tim Lavin, Kathryn M. Brennan, Michael S. Zandi, Dipa Jayaseelan, Jane Pritchard, Robert D. M. Hadden, Hadi Manji, Hugh J. Willison, Simon Rinaldi, Aisling Carr, Michael P. Lunn · 发表于：Brain · 年份：2020 · DOI：10.1093/brain/awaa433 · 被引用次数：328 · 研究领域：Peripheral Neuropathies and Disorders、Long-Term Effects of COVID-19、Retinal and Optic Conditions

Reports of Guillain-Barré syndrome (GBS) have emerged during the Coronavirus disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to investigate any causative association between COVID-19 infection and GBS. The epidemiology of GBS cases reported to the UK National Immunoglobulin Database was studied from 2016 to 2019 and compared to cases reported during the COVID-19 pandemic. Data were stratified by hospital trust and region, with numbers of reported cases per month. UK population data for COVID-19 infection were collated from UK public health bodies. In parallel, but separately, members of the British Peripheral Nerve Society prospectively reported incident cases of GBS during the pandemic at their hospitals to a central register. The clinical features, investigation findings and outcomes of COVID-19 (definite or probable) and non-COVID-19 associated GBS cases in this cohort were compared. The incidence of GBS treated in UK hospitals from 2016 to 2019 was 1.65-1.88 per 100 000 individuals per year. GBS incidence fell between March and May 2020 compared to the same months of 2016-19. GBS and COVID-19 incidences during the pandemic also varied between regions and did not correlate with one another (r = 0.06, 95% confidence interval: -0.56 to 0.63, P = 0.86). In the independent cohort study, 47 GBS cases were reported (COVID-19 status: 13 definite, 12 probable, 22 non-COVID-19). There were no significant differences in the pattern of weakness, time to...