Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease

作者：Fanny Eysert, Paula Fernanda Kinoshita, Arnaud Mary, Loan Vaillant-Beuchot, Frédéric Checler, Mounia Chami · 发表于：International Journal of Molecular Sciences · 年份：2020 · DOI：10.3390/ijms21249521 · 被引用次数：63 · 研究领域：Alzheimer's disease research and treatments、Mitochondrial Function and Pathology、Cholinesterase and Neurodegenerative Diseases

Alzheimer's disease (AD) is a multifactorial neurodegenerative pathology characterized by a progressive decline of cognitive functions. Alteration of various signaling cascades affecting distinct subcellular compartment functions and their communication likely contribute to AD progression. Among others, the alteration of the physical association between the endoplasmic reticulum (ER) and mitochondria, also reffered as mitochondria-associated membranes (MAMs), impacts various cellular housekeeping functions such as phospholipids-, glucose-, cholesterol-, and fatty-acid-metabolism, as well as calcium signaling, which are all altered in AD. Our review describes the physical and functional proteome crosstalk between the ER and mitochondria and highlights the contribution of distinct molecular components of MAMs to mitochondrial and ER dysfunctions in AD progression. We also discuss potential strategies targeting MAMs to improve mitochondria and ER functions in AD.