Association between sarcopenia and cognitive impairment in community-dwelling population

作者：Hui Zhu, Heng-Dong Li, Beili Feng, Lu Zhang, Zaixing Zheng, Yue Zhang, Dongjuan Wang, Zi Xiong, Junfei Kang, Jia-Chang Jin, Jie Lin, Honghua Ye · 发表于：Chinese Medical Journal · 年份：2020 · DOI：10.1097/cm9.0000000000001310 · 被引用次数：16 · 研究领域：Nutrition and Health in Aging、Frailty in Older Adults、Nutritional Studies and Diet

Cognitive impairment is a neurodegenerative change, involving the progression from mild cognitive impairment to dementia.[1] Sarcopenia is often considered geriatric and is characterized by a progressive and generalized decrease in skeletal muscle mass and strength.[2] Interestingly, several common pathogenic mechanisms are involved in both sarcopenia and cognitive disorders. The risk factors for sarcopenia include mitochondrial dysfunction, oxidative stress, chronic inflammation, and hormonal changes, all of which are potential causes of cognitive impairment.[3] Consequently, cognitive impairment may be closely related to sarcopenia. This study aims to examine the relationship between cognitive impairment and sarcopenia among community-dwelling elderly adults. A cross-sectional survey on health and chronic disease management was conducted from November 2016 to February 2017 in the Ximen community of Ningbo, China. All included subjects were aged 65 years or older and independent in their daily lives. Subjects with serious diseases, including severe cardiac, cerebrovascular, pulmonary, musculoskeletal diseases, neurologic disorders, or cancers, were excluded. Finally, 923 subjects were recruited for the study, after excluding 124 participants who had missing data in their physical or cognitive function assessments. This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of HwaMei Hospital, University of Chinese Academy ...