CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers

作者：Junwen Chen, Jun Yang, Xiang Fei, Xia Wang, Kefeng Wang · 发表于：International Journal of Biological Sciences · 年份：2020 · DOI：10.7150/ijbs.54292 · 被引用次数：72 · 研究领域：Circular RNAs in diseases、MicroRNA in disease regulation、RNA modifications and cancer

circular RNA ciRS-7 (ciRS-7) is a type of endogenous circular RNA (circRNA) with a closed circular structure. Since Hansen first demonstrated that ciRS-7 could serve as a microRNA sponge in 2013, researchers have paid increased attention to this circRNA. ciRS-7 plays a crucial role in regulating RNA transcription, downstream gene expression, and protein production. Moreover, ciRS-7 acts as an oncogene and promotes tumor progression through competitively inhibiting miR-7 in various types of cancers. ciRS-7 has been identified to be closely associated with breast cancer, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, cervical cancer, osteosarcoma, melanoma, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer, laryngeal squamous cell carcinoma, and cholangiocarcinoma. In this review, we summarize the biological characteristics, molecular mechanisms, and future challenges of ciRS-7 in multiple tumors.