Physiological and Pathological Roles of Mammalian NEK7

作者：Zhenzhen Sun, Wei Gong, Yue Zhang, Zhanjun Jia · 发表于：Frontiers in Physiology · 年份：2020 · DOI：10.3389/fphys.2020.606996 · 被引用次数：41 · 研究领域：Protein Tyrosine Phosphatases、Ubiquitin and proteasome pathways、Mechanisms of cancer metastasis

NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation, but the detailed mechanisms of its regulation remain unclear. This review summarizes current advances in NEK7 research involving mitotic regulation, NLRP3 inflammasome activation, related diseases and potential inhibitors, which may provide new insights into the understanding and therapy of the diseases associated with NEK7, as well as the subsequent studies in the future.