Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age

作者：Samantha L Huey, Nina Acharya, Ashley Silver, Risha Sheni, Elaine A. Yu, Juan Pablo Peña‐Rosas, Saurabh Mehta · 发表于：Cochrane Database of Systematic Reviews · 年份：2020 · DOI：10.1002/14651858.cd012875.pub2 · 被引用次数：49 · 研究领域：Vitamin D Research Studies、Child Nutrition and Water Access、Vitamin K Research Studies

BACKGROUND: Vitamin D is a secosteroid hormone that is important for its role in calcium homeostasis to maintain skeletal health. Linear growth faltering and stunting remain pervasive indicators of poor nutrition status among infants and children under five years of age around the world, and low vitamin D status has been linked to poor growth. However, existing evidence on the effects of vitamin D supplementation on linear growth and other health outcomes among infants and children under five years of age has not been systematically reviewed. OBJECTIVES: To assess effects of oral vitamin D supplementation on linear growth and other health outcomes among infants and children under five years of age. SEARCH METHODS: In December 2019, we searched CENTRAL, PubMed, Embase, 14 other electronic databases, and two trials registries. We also searched the reference lists of relevant publications for any relevant trials, and we contacted key organisations and authors to obtain information on relevant ongoing and unpublished trials. SELECTION CRITERIA: We included randomised controlled trials (RCTs) and quasi-RCTs assessing the effects of oral vitamin D supplementation, with or without other micronutrients, compared to no intervention, placebo, a lower dose of vitamin D, or the same micronutrients alone (and not vitamin D) in infants and children under five years of age who lived in any country. DATA COLLECTION AND ANALYSIS: We used standard Cochrane methodological procedures. MAIN RESUL...