Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice

作者：Levi Todd, Connor Finkbeiner, Claire K. Wong, Marcus Hooper, Thomas A. Reh · 发表于：Cell Reports · 年份：2020 · DOI：10.1016/j.celrep.2020.108507 · 被引用次数：121 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Retinal Development and Disorders、Neurogenesis and neuroplasticity mechanisms

The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting that the innate immune system limits the regenerative response to injury.