Transition Metal‐Free Synthesis of Substituted Isothiazoles via Three‐Component Annulation of Alkynones, Xanthate and NH4I

作者：Jian Li, Jiaming Li, Xiaoliang Ji, Qiang Liu, Lu Chen, Yubing Huang, Yibiao Li · 发表于：Advanced Synthesis & Catalysis · 年份：2020 · DOI：10.1002/adsc.202001179 · 被引用次数：15 · 研究领域：Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

Abstract A protocol was described to access diverse isothiazoles with functionalization potential via transition metal‐free three‐component annulation of alkynones, potassium ethylxanthate (EtOCS 2 K) and ammonium iodide (NH 4 I). A sequential regioselective hydroamination/thiocarbonylation/intramolecular cyclization cascade achieved the efficient formation of consecutive C−N, C−S and N−S bonds in a one‐pot process. magnified image