The Interaction of Age and Anatomical Region Influenced Skin Biophysical Characteristics of Chinese Women

作者：Yao Pan, Xue Ma, Jinfeng Zhao, Shiyu Yan, Qi Liu, Hua Zhao · 发表于：Clinical Cosmetic and Investigational Dermatology · 年份：2020 · DOI：10.2147/ccid.s286402 · 被引用次数：19 · 研究领域：Skin Protection and Aging、Advancements in Transdermal Drug Delivery、Dermatology and Skin Diseases

BACKGROUND: Ageing is an inevitable physiology process of humans, and skin biophysical parameters change owing to genetic and environmental factors in different ethnic populations. AIM: To gain comprehensive data on the skin biophysical parameters of different anatomical regions and to explore the change trend of the skin characteristics associated with age for the indicated regions by generalized additive model. METHODS: We measured various skin biophysical parameters on forehead, cheek, chin and inner forearm of 178 Chinese women aged between 20 and 64 years living in Beijing. These parameters comprised skin hydration, transepidermal water loss (TEWL), sebum content, erythema index (EI), melanin index (MI), L*a*b* values, individual typology angle (ITA) and pH, which were quantified by non-invasive instruments. RESULTS: Comparing the skin parameters among the four test areas, we observed that the hydration, TEWL, EI and a* values were significantly higher for the face than for the forearm, but the L* and ITA values were just the opposite. The cheek was the lightest and brightest region with lowest sebum content, while the chin was much darker and the forehead was yellowish. Considering the change of the skin parameters with age, TEWL, sebum content and melanin and erythema indices had a linear relationship with age, whereas skin hydration, L, a, b, ITA and pH values exhibited a non-monotonic relationship. The turning points of these curves appeared almost at the thirties, s...