Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches

作者：Lei Zhang, Ryan Mack, Peter Breslin, Jiwang Zhang · 发表于：Journal of Hematology & Oncology · 年份：2020 · DOI：10.1186/s13045-020-00994-z · 被引用次数：86 · 研究领域：Hematopoietic Stem Cell Transplantation、Immune Cell Function and Interaction、T-cell and B-cell Immunology

Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of HSC aging. In addition, we discuss the potential mechanisms by which HSC aging is regulated.