Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults

作者：Akihiko Kitamura, Satoshi Seino, Takumi Abe, Yu Nofuji, Yuri Yokoyama, Hidenori Amano, Mariko Nishi, Yu Taniguchi, Miki Narita, Yoshinori Fujiwara, Shoji Shinkai · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2020 · DOI：10.1002/jcsm.12651 · 被引用次数：466 · 研究领域：Nutrition and Health in Aging、Body Composition Measurement Techniques、Frailty in Older Adults

BACKGROUND: There is limited evidence on sarcopenia in Asian populations. This study aimed to clarify the prevalence, associated factors, and the magnitude of association with mortality and incident disability for sarcopenia and combinations of its components among Japanese community-dwelling older adults. METHODS: We conducted a 5.8 year prospective study of 1851 Japanese residents aged 65 years or older (50.5% women; mean age 72.0 ± 5.9) who participated in health check-ups. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019 algorithm. Appendicular lean mass index (ALMI) was measured using direct segmental multi-frequency bioelectrical impedance analysis. A Cox proportional hazards regression model was used to identify associations of sarcopenia and the combinations of its components with all-cause mortality and incident disability. RESULTS: The prevalence of sarcopenia was 11.5% (105/917) in men and 16.7% (156/934) in women. Significant sarcopenia-related factors other than ageing were hypoalbuminaemia, cognitive impairment, low activity, and recent hospitalization (all P-values <0.05) among men and cognitive impairment (P = 0.004) and depressed mood (P < 0.001) among women. Individuals with sarcopenia had higher risks of mortality [hazard ratios (95% confidence interval): 2.0 (1.2-3.5) in men and 2.3 (1.1-4.9) in women] and incident disability [1.6 (1.0-2.7) in men and 1.7 (1.1-2.7) in women]. Compared with the individuals without any sarcopen...