Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient

作者：Ji Hoon Baang, Christopher Smith, Carmen Mirabelli, Andrew L. Valesano, David M. Manthei, Michael A. Bachman, Christiane E. Wobus, Michael R. Adams, Laraine Washer, Emily T. Martin, Adam S. Lauring · 发表于：The Journal of Infectious Diseases · 年份：2020 · DOI：10.1093/infdis/jiaa666 · 被引用次数：337 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、Long-Term Effects of COVID-19

We describe a case of chronic coronavirus disease 2019 (COVID-19) in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for at least 119 days. The patient had 3 admissions related to COVID-19 over a 4-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The patient's lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.