The clinical value of multimodal ultrasound for the evaluation of disease activity and complications in inflammatory bowel disease

作者：Chao Ma, Peng-Ling Huang, Nan Kang, Jie Zhang, Ming Xiao, Jiayu Zhang, Xiao-Cang Cao, Xiangchen Dai · 发表于：Annals of Palliative Medicine · 年份：2020 · DOI：10.21037/apm-20-2162 · 被引用次数：16 · 研究领域：Inflammatory Bowel Disease、Appendicitis Diagnosis and Management、Gastrointestinal motility and disorders

BACKGROUND: Inflammatory bowel disease (IBD) has the characteristics of chronic relapse and remission, which makes early diagnosis and effective evaluation of disease activity especially crucial. With the development of ultrasound technology, its role in the diagnosis and treatment of IBD is increasing. This study aimed to explore the value of multimodal ultrasound in the assessment of disease activity and complications in IBD. METHODS: Patients with clinically confirmed IBD were selected and examined with two-dimensional ultrasound, Doppler ultrasound, contrast-enhanced ultrasound (CEUS), elastography, endoscopy with biopsies, and whole-abdominal enhanced computed tomography (CT). Collect relevant laboratory data, including C-reactive protein, erythrocyte sedimentation rate, etc. Endoscopy is used as the gold standard for disease activity assessment, and the diagnostic value of each ultrasound parameter is compared separately, and correlation analysis is made. RESULTS: Intestinal maximum wall thickness in patients in the disease activity group (active group) was significantly thicker than that in patients in remission group (7.93±2.65 vs. 4.16±1.08 mm, P<0.001). The mean values of Peak Enhancement (PE) and the area under the receiver operating characteristic (ROC) curve (AUC) were higher in the active stage than in remission, with a significant difference (-40.66±4.81 vs. -50.47±5.03 db, 356.44±170.67 vs. 194.42±92.09 dBsec, both P<0.05). Time To Peak (TTP) showed no signifi...