Cell relay-delivery improves targeting and therapeutic efficacy in tumors

作者：Ye Feng, Qianqian Liu, Yi Li, Han Yang, Meng Liang, Hao Wang, Qing Yao, Yuli Wang, Meiyan Yang, Zhiping Li, Wei Gong, Yang Yang, Chunsheng Gao · 发表于：Bioactive Materials · 年份：2020 · DOI：10.1016/j.bioactmat.2020.11.014 · 被引用次数：38 · 研究领域：Phagocytosis and Immune Regulation、Nanoplatforms for cancer theranostics、Nanoparticle-Based Drug Delivery

Cell-mediated drug delivery system (CDDS) has shown great potential for cancer therapy. However, a single cell-mediated drug delivery mechanism has not generally been successful, particularly for systemic administration. To augment the antitumor therapy efficacy, herein, we propose a strategy of cell relay-delivery for the use of artificially damaging/aging erythrocytes to hitchhike on circulating monocytes/macrophages for intratumoral accumulation of anticancer drugs. This biomimetic relay-delivery strategy was derived from the manner in which circulating monocytes/macrophages in body specifically engulf damaged/senescent erythrocytes and actively transmigrate into the tumor bulk. The strategy elegantly combines the natural functions of both cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. According to the strategy, we developed biotinylated erythrocyte-poly (lactic-co-glycolic acid) (PLGA) nanoparticle hybrid DDSs (bE-NPs) using avidin-biotin coupling. In such a system, biotinylated erythrocytes can mimic the natural property of damaged/senescent erythrocytes, while PLGA NPs are capable of encapsulating anticancer drugs and promoting sustained drug release. Anticancer drugs can effectively target tumor sites by two steps. First, by using biotinylated erythrocytes as the carrier, the drug-loaded PLGA NPs could be specifically phagocytized by monocytes/macrophages. Second, by taking advantage of the tumor-tropic property of mo...