Clinical and Pathological Features of Prostatic Stromal Tumor of Uncertain Malignant Potential: A Retrospective Study of 23 Chinese Cases

作者：Qi Shen, Zhaohui Zhou, Zhenhua Liu, Shuai Hu, Zhiyong Lin, Shaobo Li, Senmao Li, Hualin Song, Yuke Chen, Yisen Meng, Yu Wang, Yu Fan, Xin Li, Yunxiang Xiao, Qun He, Jie Jin, Qian Zhang, Wei Yu · 发表于：Urologia Internationalis · 年份：2020 · DOI：10.1159/000508763 · 被引用次数：10 · 研究领域：Urologic and reproductive health conditions、Prostate Cancer Diagnosis and Treatment、Prostate Cancer Treatment and Research

Introduction: Prostatic stromal tumor of uncertain malignant potential (STUMP) is a rare disease that may coexist with prostate stromal sarcoma (PSS). We aimed to analyze the histological and clinical features of STUMP. Methods: Twenty-three patients diagnosed with STUMP from 2008 to 2019 were included. Clinicopathological and follow-up information was collected. In the subgroup analysis, we divided the patients into a pure STUMP group (N = 18) and a mixed STUMP (STUMP coexisting with PSS) group (N = 5). Student’s t test was used to compare the 2 groups. Results: Patients had a mean age of 55.5 ± 19.4 years and an average follow-up time of 42.3 months. The mean prostate volume was 109.2 ± 73.5 cm3, and the mean prostate-specific antigen was 8.03 ± 10.5 ng/mL. In the subgroup analysis, 16.7% (2/12) of pure STUMP patients had disease progression, while 100% (3/3) of mixed STUMP patients suffered from recurrence. Compared with the pure STUMP group, the mixed STUMP group was younger (37.2 vs. 60.6 years, p = 0.013) and had lower expression of estrogen receptor and progesterone receptor (p = 0.004 and p &#x3c; 0.001, respectively). Conclusion: STUMP is a rare disease with a relatively good pro...