Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol

作者：Mandy Xian Hu, Christina Palantza, Kim Setkowski, Renske Gilissen, Eirini Karyotaki, Pim Cuijpers, Heleen M. Riper, Derek Paul De Beurs, Chani Nuij, Helen M Christensen, Alison L. Calear, Aliza Werner‐Seidler, Adriaan W. Hoogendoorn, Anton van Balkom, Merijn Eikelenboom, Jan Smit, Wouter van Ballegooijen · 发表于：BMJ Open · 年份：2020 · DOI：10.1136/bmjopen-2020-037566 · 被引用次数：9 · 研究领域：Suicide and Self-Harm Studies、Meta-analysis and systematic reviews、Mental Health Research Topics

INTRODUCTION: Psychotherapy may reduce suicidal thoughts and behaviour, but its effectiveness is not well examined. Furthermore, conventional meta-analyses are unable to test possible effects of moderators affecting this relationship. This protocol outlines the building of a comprehensive database of the literature in this research field. In addition, we will conduct an individual patient data meta-analysis (IPD-MA) to establish the effectiveness of psychotherapy in reducing suicidality, and to examine which factors moderate the efficacy of these interventions. METHODS AND ANALYSIS: To build a comprehensive database, randomised controlled trials examining the effect of any psychotherapy targeting any psychiatric disorder on suicidal thoughts or behaviour will be identified by running a systematic search in PubMed, Embase, PsycINFO, Web of Science, Scopus and The Cochrane Central Register of Controlled Trials from data inception to 12 August 2019. For the IPD-MA, we will focus on adult outpatients with suicidal ideation or behaviour. In addition, as a comparison group we will focus on a control group (waiting-list, care as usual or placebo). A 1-stage IPD-MA will be used to determine the effectiveness of psychotherapy on suicidal ideation, suicide attempts and/or suicide deaths, and to investigate potential patient-related and intervention-related moderators. Subgroup and sensitivity analyses will be conducted to test the robustness of the findings. Additionally, a conventiona...