Estimated SARS-CoV-2 Seroprevalence in the US as of September 2020

作者：Kristina L. Bajema, Ryan E. Wiegand, Kendra M. Cuffe, Sadhna Patel, Ronaldo Iachan, Travis Lim, Adam Lee, Davia Moyse, Fiona P. Havers, Lee E. Harding, Alicia M. Fry, Aron J. Hall, Kelly J. Martin, Marjorie Biel, Yangyang Deng, William A. Meyer, Mohit Mathur, Tonja M. Kyle, Adi V. Gundlapalli, Natalie J. Thornburg, Lyle R. Petersen, Chris Edens · 发表于：JAMA Internal Medicine · 年份：2020 · DOI：10.1001/jamainternmed.2020.7976 · 被引用次数：327 · 研究领域：SARS-CoV-2 and COVID-19 Research、SARS-CoV-2 detection and testing、COVID-19 Clinical Research Studies

Importance: Case-based surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection likely underestimates the true prevalence of infections. Large-scale seroprevalence surveys can better estimate infection across many geographic regions. Objective: To estimate the prevalence of persons with SARS-CoV-2 antibodies using residual sera from commercial laboratories across the US and assess changes over time. Design, Setting, and Participants: This repeated, cross-sectional study conducted across all 50 states, the District of Columbia, and Puerto Rico used a convenience sample of residual serum specimens provided by persons of all ages that were originally submitted for routine screening or clinical management from 2 private clinical commercial laboratories. Samples were obtained during 4 collection periods: July 27 to August 13, August 10 to August 27, August 24 to September 10, and September 7 to September 24, 2020. Exposures: Infection with SARS-CoV-2. Main Outcomes and Measures: The proportion of persons previously infected with SARS-CoV-2 as measured by the presence of antibodies to SARS-CoV-2 by 1 of 3 chemiluminescent immunoassays. Iterative poststratification was used to adjust seroprevalence estimates to the demographic profile and urbanicity of each jurisdiction. Seroprevalence was estimated by jurisdiction, sex, age group (0-17, 18-49, 50-64, and ≥65 years), and metropolitan/nonmetropolitan status. Results: Of 177 919 serum samples tested, 103 ...